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FiREBOLT: LY4337713 in Adults with FAP-Positive Solid Tumors - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out if an experimental drug called LY4337713 (the study drug) is a safe and effective option for people who have FAP-positive solid tumors. The study drug is a type of radiotherapy that is intended to target and attach only to FAP. The goal of targeted radiotherapy is to provide selective delivery of radiation doses that can destroy tumor cells.

What is the Condition Being Studied?

Cancers with Fibroblast Activation Protein (FAP) Positive Solid Tumors

Who Can Participate in the Study?

Adults ages 18+ who:

Are diagnosed with one of the following forms of cancer with a solid tumor present: adenocarcinoma of the pancreas, HR-positive & HER2-negative breast cancer, HER2-positive breast cancer, triple-negative breast cancer, platinum-resistant or refractory ovarian cancer, gastric adenocarcinoma, colorectal cancer, squamous cell carcinoma or adenocarcinoma esophageal cancer, or cholangiocarcinoma
Have clinical or imaging evidence of FAP expression

For more information, contact the study team at dana.a.warren@duke.edu.

Grupo etario

Adultos

What is Involved?

Si elige unirse a este estudio, podrá:

Get an intravenous (IV) injection of the study drug either every 4 weeks or every 6 weeks, depending on when you are enrolled
Hacer extracciones de sangre y dar muestras de orina
Realice tomografías computarizadas o resonancias magnéticas de manera regular.

Study Details

Full Title

A Dose Escalation and Dose Optimization Phase 1a/1b Study to Evaluate Safety, Tolerability and Dosimetry of Radioligand Therapy with LY4337713 in Adults with FAP-Positive Solid Tumors (FiREBOLT)

Principal Investigator