LY3962673 for KRAS G12D-mutated solid tumors - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out if an experimental drug called LY3962673 (the study drug) is a safe and effective option for cancer that has a KRAS G12D mutation. We are also trying to find the best dose level to use.

What is the Condition Being Studied?

Solid Tumors with KRAS G12D Mutation

Who Can Participate in the Study?

Adults ages 18+ who:

  • Are diagnosed with a solid tumor form of cancer
  • Have disease that is inoperable, advanced, or metastatic
  • The tumor tests positive for a KRAS G12D mutation

For more information, contact the study team at dana.a.warren@duke.edu.

Grupo etario
Adultos

What is Involved?

Si elige unirse a este estudio, podrá:

  • Take the study drug by mouth once or twice every day
  • Depending on which arm of the study you are in, you may also get standard anti-cancer drugs every 1 to 2 weeks
  • Hágase biopsia del tumor
  • Give blood and urine samples
  • Realice tomografías computarizadas o resonancias magnéticas de manera regular.

Study Details

Full Title
[J5J-OX-JZZA] A Phase 1a/1b Trial of LY3962673 in Participants with KRAS G12D-Mutant Solid Tumors
Principal Investigator
Especialista en oncología médica
Protocol Number
IRB: PRO00116471
NCT: NCT06586515
Phase
Fase I
ClinicalTrials.gov
Estado de inscripción
Abierto para inscripción
Participate