BMT CTN 2207 CureAA (Aplastic Anemia) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out if patients with SAA who have not received previous treatment for this diagnosis can be treated safely and effectively with transplant as their first therapy.

What is the Condition Being Studied?

Severe Aplastic Anemia (SAA)

Who Can Participate in the Study?

Children and Adults ages 3-75 who:

Are diagnosed with SAA
Do not have a suitable, fully matched related donor
Have a left ventricular ejection fraction > 40% with no signs of heart failure, or an ejection fraction > 26% if less than 13 years old

For more information about who can join this study, please contact the study team at quinna.marshburn@duke.edu.

Grupo etario

Adultos

What is Involved?

If you or your child choose to join the study, you/they will:

Receive a combination of chemotherapy drugs (fludarabine and cyclophosphamide) before you/they get your/their donor cells
Get bone marrow donor cells as an IV (intravenous) infusion

Study Details

Full Title

A Phase II Trial of Non-Myeloablative Conditioning and Transplantation of Haploidentical Related, Partially HLA-Mismatched, or Matched Unrelated Bone Marrow for Newly Diagnosed Patients with Severe Aplastic Anemia

Principal Investigator