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Xenon MRI E-Cig (Study for Health Volunteers) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to determine the impact of smoking electronic cigarettes (e-cigs) on lung health. This will be done by comparing study procedures and imaging results between healthy participants that use e-cigs versus those who don't.

What is the Condition Being Studied?

Healthy Volunteers

Who Can Participate in the Study?

Adults ages 18-35 who are in general good health can participate as either e-cigarette users or non-users if they meet the following criteria:

E-cigarette users

Have used e-cigarettes for at least 6 months
Do not have more than a 1 pack year history of smoking traditional tobacco cigarettes (1 pack year = smoking 1 pack of cigarettes per day for 1 year)
Have no history of lung, kidney, or liver disease
Have no history of stroke, brain damage, or dementia
Are not pregnant

E-cigarette non-users

Have never used e-cigarettes and do not currently smoke
Do not have more than a 1 pack year history of smoking traditional tobacco cigarettes (1 pack year = smoking 1 pack of cigarettes per day for 1 year)
Have no history of lung, kidney, or liver disease
Have no history of stroke, brain damage, or dementia
Are not pregnant

For more information, contact the study team at cody.blanton@duke.edu.

Grupo etario

Adultos

What is Involved?

If you choose to join this study, it will involve 5 study visits, lasting up to 4 hours each. This includes a screening visit and 4 procedure visits, with the last 2 visits at a 12- month follow-up.

Study procedures will include:

Cardiopulmonary exercise testing
Función pulmonar
Electrocardiograms
Multiple dimensional computed tomography
Physical exam and basic body measurements such as temperature, heart rate, and blood pressure
Blood and urine collection
Health questionnaires
Hyperpolarized xenon magnetic resonance imaging (this is a special type of MRI where you breathe in a small bag of xenon gas and hold your breath while in the MRI scanner)