AbelZeta_CTIL051 (Non-Small Cell Lung Cancer) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out if the combination of 2 experimental drugs called C-TIL051 and NKTR-255 when they are given along with pembrolizumab is a safe and effective option for non-small cell lung cancer (NSCLC). C-TIL051 is custom-made for each participant from their own tumor tissue. Immune cells are isolated from your tumor tissue, regrown in a lab, and then formulated to be returned to your bloodstream. We want to know if C-TIL051 can help people's immune systems target and destroy cancer cells. NKTR-255 is designed to help C-TIL051 work better.

What is the Condition Being Studied?

Cáncer de pulmón de células no pequeñas (CPCNP)

Who Can Participate in the Study?

Adults ages 18 or older who:

  • Are diagnosed with NSCLC
  • Have not received checkpoint inhibitor therapy
  • Have tumor tissue that can be surgically removed
  • Have never received treatment with a cellular therapy

Para obtener más información sobre quién puede participar en este estudio, comuníquese con el equipo del estudio al 919-681-6468.

Grupo etario
Adultos

What is Involved?

Si elige unirse a este estudio, podrá:

  • Undergo surgery to collect your tumor tissue to make the study drug
  • Receive lympho-depleting chemotherapy
  • Take the study drugs
  • Realizarse exámenes físicos y extracciones de sangre
  • Have imaging scans (CT and/or MRI)
  • Have heart tests (ECG)

Study Details

Full Title
C-TIL051 in Anti-PD1 Resistant Metastatic Non-Small Cell Lung Cancer
Principal Investigator
Especialista en oncología médica
Protocol Number
IRB: PRO00112188
NCT: NCT05676749
Phase
Fase I
ClinicalTrials.gov
Estado de inscripción
Abierto para inscripción
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