ARC-21 (Gastrointestinal Cancer) - Clinical Trial

or email

gi-oncology-cru@dm.duke.edu

What is the Purpose of this Study?

We are doing this study to see if the study drugs, domvanalimab and zimberelimab, are safe and effective for treating advanced or metastatic gastroesophageal adenocarcinoma.

What is the Condition Being Studied?

Gastroesophageal Adenocarcinoma

Who Can Participate in the Study?

Adults ages 18+ who are diagnosed with one of the following types of cancer:

Esophageal adenocarcinoma (a common type of cancer of the esophagus); OR
Gastroesophageal junction adenocarcinoma (cancer where the esophagus meets the stomach); OR
Gastric adenocarcinoma (stomach cancer)

The cancer must not be treatable with surgery alone.

Para obtener más información sobre quién puede participar en este estudio, comuníquese con el equipo del estudio al 919-668-1861.

Grupo etario

Adultos

What is Involved?

Si elige unirse a este estudio, podrá:

Receive the study drugs, domvanalimab and zimberelimab, through an IV once every 3 or 4 weeks
Receive standard chemotherapy every 2 weeks in addition to the study drugs (if not previously treated)
Realizar extracciones de sangre
Get CT or MRI scans every 6-to-12 weeks

Study Details

Full Title

A Phase 2 Trial to Evaluate the Safety and Efficacy of Domvanalimab (AB154) and Zimberelimab (AB122) -Based Treatment Combinations in Patients with Advanced Upper Gastrointestinal Tract Malignancies

Principal Investigator